Brand: YC
Model: cheryl@chembj.com
Price: USD 1 / gram
Min. Order: 5g gram
Reducing Fat Mass Chemicals
SR9011 CAS: 1379686-30-2
Molucelar Formula: C23H31ClN4O3S
Molucelar weight: 479.03524
Type:Analysis reagent
Grade Standard:Medicine Grade
Purity:99.5%(HPLC)
Apprarance:White powder.
Application:
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic
Standard:USP
Use:In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays. In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
----------Additional Information ------------
Place of origin : China
Brand : YC
Certificate : ISO9001, KOSHER, GMP, SGS
Minimum order quantity : 5 Grams
Production capacity : 1000 Kilograms/Month

-----------Delivery Information -------------
Packing : Foil bag/tin or as your request
Payment : T/T, Western Union, MoneyGram
Port : Shanghai, Shenzhen, Hongkong
Shipment method : EMS, DHL, FeDex, UPS, etc
Leading time : Within 24 hours after payment
Delivery time : safe & timely, around 4 days after payment.

----------Our Competitive Advantages -----------
1,Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years
2,Great quality, purity and favourable.
Our company is a professional leading factory in China in pharmaceutical area.Good quality is one of our secret success.
3,Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
4,Package: Professional packing with professional materials
5,Competitive Prices : Low price with high qulity
6,Good after-sales service : making all efforts to meet customers' need.