Brand: YC
Model: Skype: tom131393
Price: USD 1 / g
Min. Order: 10 g g
SGC0946 CAS:1561178-17-3

Product Name: SGC0946
CAS: 1561178-17-3
MF: C28H40BrN7O4
storage temp. -20°C
Purity : 99%
Appearance : White powders
Package : 1kg/foil bag
Usage : SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.

In vitro :
SGC 0946 is over 100-fold selective for other histone methyltransferases/HMTs. SGC 0946 potently reduces H3K79 dimethylation with IC50 of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells, which potently and selectively kills cells containing an MLL translocation. SGC 0946 is much more potent than its close analog EPZ004777, and serves as an excellent chemical probe for investigating DOT1L and further development of DOT1L inhibitors for cancer therapy.

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