Brand: YC
Model: Skype: tom131393
Price: USD 1 / g
Min. Order: 10 g g
AZD-8055 CAS: 1009298-09-2

Product Name: AZD-8055
CAS: 1009298-09-2
MF: C25H31N5O4
MW: 465.54474
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;PI3K/Akt/mTOR
density: 1.248
Purity : 99%
Appearance : White powders
Package : 1kg/foil bag
Usage:
1.A novel ATP-competitive inhibitor of mTOR with an IC50 of 0.8 nM.
2.A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.

Related mTOR Products :
MHY1485 CAS: 326914-06-1
CHIR-99021 (CT99021) CAS: 252917-06-9
Dorsomorphin (Compound C, BML-275) CAS: 866405-64-3
Rapamycin (Sirolimus) CAS: 53123-88-9
Everolimus (RAD001) CAS: 159351-69-6
Torin 1 CAS: 1222998-36-8
Temsirolimus (CCI-779, NSC 683864) CAS: 162635-04-3
INK 128 (MLN0128) CAS: 1224844-38-5
KU-0063794 CAS: 938440-64-3
BEZ235 (NVP-BEZ235, Dactolisib) CAS: 915019-65-7 / CAS: 1028385-32-1
MK-2206 2HCl CAS: 1032350-13-2
Trametinib (GSK1120212) CAS: 871700-17-3
Olaparib (AZD2281, Ku-0059436) CAS: 763113-22-0