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Sr9011 Cas: 1379686-29-9 (Steroid E-Mail: Tom@Chembj.Com)

Detailed Selling Lead Description
Brand: YC
Model: Skype: tom131393
Price: USD 1 / g
Min. Order: 10 g g
SR9011 CAS: 1379686-29-9

Product name: SR9011
CAS: 1379686-29-9
Molucelar Formula: C23H31ClN4O3S
Molucelar weight: 479.03524
Type: Analysis reagent
Grade Standard: Medicine Grade
Purity: 99.5%(HPLC)
Apprarance: White powder
Standard: USP

Application:
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic

________________________________ For Your Reference ________________________________
Place of origin : China
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Quality Standard : USP
Minimum Order Quantity : 10 g
Production Capacity : 1000 Kg/Month

________________________________ Package & Delivery ________________________________
Package : Foil bag, Foil tin , Drum or as your request
Payment Method : T/T, Western Union, MoneyGram, Bitcoin
Port of Loading : Shanghai, Shenzhen, Hongkong
Shipping Method : By Sea , By Air or Express: EMS, DHL, FeDex, UPS (Note: Best Choice For you will be adopted)
Leading time : Within 1 day upon confirming payment
Delivery time : Within 6 working days upon confirming payment (Note: door to door service)
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