Brand: zzyc
Model: 10238-21-8
Min. Order: 10g
English Synonyms: LABOTEST-BB LT00244861;GLYBENCLAMIDE;GLYBENZCYCLAMIDE;GLYBURIDE;GIBENCLAMIDE;GLIBENCLAMIDE;5-CHLORO-N-[4-(CYCLOHEXYLUREIDOSULFONYL)PHENETHYL]-2-METHOXYBENZAMIDE;5-CHLORO-N-[2-[4-[ [[(CYCLOHEXYLAMINO)CARBONYL]AMINO]-SULFONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE
    Glibenclamide, also known as glibenclamide, Dana treatment, is a second-generation oral sulfonylurea hypoglycemic agent. Its mechanism of action is tolbutamide, its hypoglycemic effect is the strongest in sulfonylurea, and its strength is 200-250 times of tolbutamide. It can selectively act on pancreatic β cells, promote the secretion of insulin, increase the hypoglycemic effect of exogenous insulin, and strengthen the postreceptor action of insulin. Oral absorption is fast, protein binding rate is high, it begins to take effect in 30 minutes, and it is the strongest in 1.5 hours, lasting 16 to 24 hours. The volume of distribution is 0.1L/kg, the plasma protein binding rate is 90% to 95%, and the half-life is 4 to 8 hours. Mainly metabolized by the liver, there are six metabolites, known as two kinds of hydroxyl compounds, no hypoglycemic effect, mainly from the urine, a small amount of fecal discharge. Mainly for the treatment of mild, moderate non-insulin-dependent diabetes mellitus