Brand: zzyc
Model: 34580-14-8
Min. Order: 10g
CAS: 34580-14-8
EINECS: 252-100-0
Molecular Formula: C23H23NO5S
Molecular weight: 425.4974
Melting point: 192 °C
Ketotifen fumarate, also known as mephimidone, thiabendrone, salidomone, thiabantone, and ketotifen, is a powerful antiallergic agent with both tricyclic and piperidine structures. It is a combination of strong histamine H1 receptor antagonism and inhibition of allergic reaction mediator release. It can inhibit the release of many mediators of mast cells, basophils and macrophages, including the release of slow-responsive substances and other active substances, has an antagonistic effect on calcium ions, inhibits phosphodiesterase, and induces cAMP in mast cells. Increased content. Inhibiting the chemotaxis and inflammatory response of neutrophils, its effect is 10 times stronger than chlorpheniramine, and has a long-acting effect, and is stronger than sodium cromolyn. Ketotifen fumarate has therapeutic effects on both type I and type III allergy. Peak blood concentration of 2 to 3 hours, half-life of 22 hours, 60% excretion via the urine, 40% excreted by the feces, children excreted faster than adults, long-term treatment does not produce drug resistance, interruption of treatment without rebound phenomenon.