Brand: zzyc
Model: 434-16-2
Min. Order: 10g
Product Description:
CAS: 434-16-2
MF: C27H44O
MW: 384.64
EINECS: 207-100-5

7-Dehydrocholesterol is a zoosterol that functions in the serum as a cholesterol precursor, and is converted to vitamin D3 in the skin, therefore functioning as provitamin-D3. The presence of this compound in human skin enables humans to manufacture vitamin D3 from ultra-violet rays in the sun light, via an intermediate isomer pre-vitamin D3. It is also found in the milk of several mammalian species. In insects it is a precursor for the hormone ecdysone, required for reaching adulthood.It was discovered by Nobel-laureate organic chemist Adolf Windaus

Synthesis of pre-vitamin D3 in the skin involves UVB radiation which effectively penetrates only the epidermal layers of skin. 7-Dehydrocholesterol absorbs UV light most effectively at wavelengths between 290-320nm and thus the production of vitamin D3 will only occur at those wavelengths. The two most important factors that govern the generation of pre-vitamin D3 are the quantity (intensity) and quality (appropriate wavelength) of the UVB irradiation reaching the 7-dehydrocholesterol deep in the stratum basale and stratum spinosum.[4] Another important consideration is the quantity of 7-dehydrocholesterol present in the skin. Under normal circumstances, ample quantities of 7-dehydrocholesterol (about 25-50 mg/cm2 of skin) are available in the stratum spinosum and stratum basale of human skin to meet the body's vitamin D requirements.

Usage:
1. Important intermediate in the synthesis of vitamin D3
2. Skin sunscreen additive in cosmetics
3. Other laboratory reagents