Price: USD 437.3 / kg
Min. Order: 1 kg
CAS no. : 474-25-9
Molecular formula: C24H40O4
Molecular weight: 392.57
MDL number: MFCD00064142
Beilstein number: 3219887
EC: 207-481-8
2 physical and chemical properties of this product is colorless needle crystal, odourless, taste bitter.Almost insoluble in water, soluble in ethanol, ice acetic acid, slightly soluble in chloroform.
3 role dosage of this product is currently the world's one of the largest drug for gallstones, and synthetic bear bile acid (UDCA) to oxygen and other steroid compound materials.
By bile extract four sources.
Specification: HPLC98 %, 90%
5 pharmacokinetic and clinical use of CDCA is Gao Huaxue pure contain different crystal forms of cholic acid type no. Combining.It dissolves in the gut soon, no matter on an empty stomach or with food and clothing, 500 ~ 750 mg often use almost completely absorbed.A small number of combined with plasma protein, free in the peripheral blood type remain low.Part of the bile duct into the lumen and absorbed by weight, form the enterohepatic circulation.Liver can effectively absorb and clear, the first effect is 62%.CDCA combined with glycine and taurine in the liver, in bile secretion, combining type CDCA can absorb, and more clear by the liver.In intestinal type combination can be free again, into the new intake of bile acid pool, drugs that are not absorbed by the droppings or oxygen into the bear to cholic acid (UDCA), but most of the coliform cluster after 7 alpha hydroxy off decomposition into Lithocholic acid (Lithocholic acid, LCA), LCA is the main metabolites of after oral CDCA, normal human body about 1/5 the terminal ileum and colon absorption, the rest of the formation of bile salts from feces excretion.LCA primarily in the liver and kidney in the sulfuric acid salinization, lower the toxicity of the liver.LCA of sulfate in the intestinal absorption, rarely with the eduction of excrement and urine, so the sulfuric acid salinization can prevent the enterohepatic circulation of LCA in savings.
Dosage of chenodeoxycholic acid is one of the world, one of the largest drug for gallstones and synthetic bear bile acid (UDCA) to oxygen and other steroid compound materials.
Chenodeoxycholic acid (CDCA) main function is to reduce cholesterol in bile saturation, the vast majority of patients after taking CDCA (when CDCA accounted for 70% of bile salts in bile), lipid micelles recovery state, cholesterol is in unsaturated state, thus make stone cholesterol dissolved, fall off.Large doses of CDCA daily (10 ~ 15 mg/kg) can inhibit the synthesis of cholesterol, and increase the secretion of bile cholelith disease patients, but the amount of secretion of bile salt and lecithin remain unchanged.
Chenodeoxycholic acid is mainly used to bear to cholic acid oxygen intermediates.