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Price: USD 1 / g
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Pharmaceutical Intermediates Acadesine Treatment Of Cardiovascular Diseases CAS: 2627-69-2

Alias: AICAR;AICA-RIBOSIDE;AMPK;Z-RIBOSIDE
CAS: 2627-69-2
Assay: 98%
EINECS: 220-097-5
M.F.: C9H14N4O5
M.W.: 258.23
M.S.:

M.P.: 214-215 °C
Storage instructions：Store at -20°C (desiccating conditions).
Solubility overview：Soluble in water to 50 mM and in DMSO to 100 mM (with heating)
Properties: white or off-white powder.
Usage: pharmaceutical intermediates.For the treatment of cardiovascular diseases.

Functions:
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.


Biological Activity:
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.

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