Brand: muscle man
Price: USD 1 / g
Min. Order: 10g g
DNP (2,4-Dinitrophenol)

Alias: 2 4-DINITROPHENOL INDICATOR; 2,4-DINITROPHENOL PESTANAL
CAS: 51-28-5
EINECS: 200-087-7
M.F.: C6H4N2O5
M.W. :184.11
M.S.:

M.P.: 108-112 °C
Assay: 98%
Melting point: 112 ~ 114 ℃
Stability: flammable
Toxicity: inhalation, ingestion or skin contact with poison, and the accumulative damage storage method: sealed in a cool dark place to preserve
Appearance: light yellow to yellow orthorhombic crystal
Usage: used for explosives, dyes, organic synthesis
HS:2908991090

Description:

2,4-Dinitrophenol (2,4-DNP, or simply DNP) is an organic compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline solid that has a sweet, musty odor. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions.It is a precursor to other chemicals and is biochemically active, inhibiting energy (ATP) production in cells with mitochondria and was once used as a diet aid.
2,4-Dinitrophenol is produced by hydrolysis of 2,4-dinitrochlorobenzene.
DNP by some bodybuilders and athletes to rapidly reduce body fat content. Although many people think that DNP is dangerous for the human body, which is itself an efficient action principle is still considered to be studied, in order to seek potential treatment of obesity drugs. At present, the research focuses on the human body naturally occurring uncoupling protein.

Applications:
DNP, its role is to make the de-coupling of oxidation and phosphorylation. Once given to 10-4M concentration of mitochondria, the uncoupling effect occurs, oxygen absorption is increased, P: O decline, if further given the high concentration will hinder the absorption of oxygen. DNP as a mechanism of action uncoupler is: DNP did not inhibit transfer of electrons, but it can eliminate the proton driving force required for the synthesis of ATP. Since DNP is a lipophilic compound is weakly acidic, it passes through the neutral state proton mitochondrial inner membrane lipid bilayer. When there is a proton gradient across the membrane, it is incorporated in the acidic side of the membrane proton to become a neutral state uncharged, by diffusion through the membrane, and in the alkaline side of the membrane to release a proton, thereby neutralized cross membrane proton gradient.

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