Generally, tissue factor is an integral membrane glycoprotein expressed in the plasma membrane of many cell types. It plays an important, physiological role in hemostasis and thrombogenesis. When the body is injured, tissue factor becomes exposed to blood at the site of vascular injury, combines with FVIIa, a protein in serum, to form complex, and then initiates blood coagulation. In recent years, many investigations have shown that the increased serum level of tissue factor is closely associated with many serious diseases such as acute coronary syndrome, atherosclerosis, disseminated intravascular coagulation (DIC), and some malignant solid tumors. In addition, tissue factor has many other biological activities, for example, it is involved in many signaling pathways, including those related to inflammatory response, angiogenesis, and cell migration.